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Research groups
  Molecular Microbiology

General data

Field of study:
Experimental Sciences
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Telephone:
+34 965903400 x 9761
Telephone:
+34 96 590 2162

Annual reports

Annual report
  • Study of repeated sequences in prokaryotes
    Caracterización de las secuencias repetidas CRISPR (Clustered regularly interspaced short palindromic repeats) de procariotas. Significado funcional y aplicaciones en tipificación molecular. Implicaciones evolutivas. Componentes de un sitema de inmunidad frente a elementos genéticos foráneos basado en las repeticiones CRISPR. Aplicaciones en biotecnología y clínica.

 

 

Services offered

Growth and manipulation of microorganisms. Detection and identification of microorganisms by molecular and culture methods. Genetic modification of prokaryotes. Analysis of gene expression in prokaryotes. Microbiological analysis of food.

 

 

Results

Identification in prokaryotes of a new genetic barrier against transmissible elements (plasmids and viruses) Development of a method for molecular typing of prokaryotes based on PCR amplification of CRISPR elements. Induction in prokaryotes of immunity against virus infection. Identification of virus components to be used as antibacterials.

 

 

Available relevant infrastructure

Basic equipment for experimentation in microbiology and molecular biology.

 

 

RELEVANT CONTRIBUTIONS TO RESEARCH PROJECTS
  • Project title: Agente de innovación para potenciar la transferencia de la tecnología generada en la Universidad de Alicante en el campo de la Microbiología al entono empresarial de la Comunidad ValencianaING
    Reference: INNTA1/2020/25
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: AGENCIA VALENCIANA DE LA INNOVACION
    Starting date: 01/01/2020
    Termination date: 31/12/2021
  • Project title: Detección y caracterización de nuevos sistemas CRISPR-CasING
    Reference: PROMETEO/2017/129
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: GENERALITAT VALENCIANA
    Starting date: 01/11/2017
    Termination date: 31/10/2021
  • Project title: Bacteriophage lysins as alternatives to antimicrobial treatment - BLAATING
    Reference: 291815 Era Net - ANIHWA
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: MINISTERIO DE ECONOMIA Y EMPRESA
    Starting date: 01/04/2016
    Termination date: 31/03/2019
  • Project title: Inmunización en bacterias: adaptación del sistema CRISPR-Cas-I-E de Escherichia coli y Salmonella entericaING
    Reference: BIO2014-53029-P
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: MINISTERIO DE ECONOMIA Y EMPRESA
    Starting date: 01/01/2015
    Termination date: 31/12/2019
  • Project title: Caracterización del sistema CRISPR/CAS-Y de Escherichia coliING
    Reference: BIO2011-24417
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: MINISTERIO DE ECONOMIA Y EMPRESA
    Starting date: 01/01/2012
    Termination date: 31/12/2014
  • Project title: Investigación del sistema CRISPR-Cas IV-BING
    Reference: PID2023-150750NB-I00
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: MINISTERIO DE CIENCIA, INNOVACION Y UNIVERSIDADES
    Starting date: 01/09/2024
    Termination date: 31/12/2027
  • Project title: (PERIODICA-FI) FONDO DE INVESTIGACIÓN IVA SI ING
    Reference: PERIODICA-FI
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: UNIVERSIDAD DE ALICANTE
    Starting date: 30/05/2024
    Termination date: 31/12/2050
  • Project title: Biotecnología de Extremófilos (BIOTECEXTREM) - VIGROB-016 ING
    Reference: VIGROB23-016
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: UNIVERSIDAD DE ALICANTE
    Starting date: 01/01/2024
    Termination date: 31/12/2024
  • Project title: Biotecnología de Extremófilos (BIOTECEXTREM) - VIGROB-016 ING
    Reference: UADIF23-39
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: UNIVERSIDAD DE ALICANTE
    Starting date: 01/01/2024
    Termination date: 31/12/2024
  • Project title: Caracterización, optimización y validación de nuevas proteínas Cas para la mejora genética de cultivos estratégicos de la Comunidad Valenciana.ING
    Reference: INNEST/2024/427
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: AGENCIA VALENCIANA DE LA INNOVACION
    Starting date: 01/01/2024
    Termination date: 31/12/2026

Publications See search box

RELEVANT CONTRIBUTIONS IN JOURNALS
  • Title: Identification of the EH CRISPR-Cas9 system on a metagenome and its application to genome engineering
    Authors: Esquerra, B.; Baquedano, I.; Ruiz, Raúl; Fernández, Almudena; Montoliu, Lluís; MARTINEZ MOJICA, FRANCISCO JUAN
    Journals Microbial Biotechnology
    Volume:
    Pages: -
    Date: 2023
    ISSN: 1751-7915
    DOI: http://dx.doi.org/10.1111/1751-7915.14266
  • Title: Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins
    Authors: Alonso-Lerma, B; Jabalera, Y; Samperio, S; Morin, M; Fernandez, A; Hille, LT; Silverstein, RA; Quesada-Ganuza, A; Reifs, A; Fernández-Peñalver, S; , Benitez, Y.; Soletto, L; Gavira, JA; Diaz, A; Vranken, W; Sanchez-Mejias, A; Güell, M; Mojica, FJM; Kleinstiver, BP; Moreno-Pelayo, MA; , Montoliu, L.; Perez-Jimenez, R
    Journals Nature Microbiology (Online)
    Volume: 8
    Pages: 77 - 90
    Date: 2023
    ISSN: 2058-5276
    DOI: http://dx.doi.org/10.1038/s41564-022-01265-y
  • Title: Global phylogenomic novelty of the Cas1 gene from hot spring microbial communities
    Authors: Salgado, Oscar; , Guajardo-Leiva, S; Moya-Beltrán, Ana; Barbosa, Carla; Ridley, Christina; Tamayo-Leiva, Javier; Quatrini, Raquel; Mojica, FJM; , Diez, Beatriz
    Journals Frontiers in Microbiology
    Volume: 13
    Pages: -
    Date: 2022
    ISSN: 1664-302X
    DOI: http://dx.doi.org/10.3389/fmicb.2022.1069452
  • Title: Digging into the lesser-known aspects of CRISPR biology
    Authors: Guzmán, NM.; Esquerra, B.; Mojica, FJM
    Journals International Microbiology
    Volume: 24
    Pages: 473 - 498
    Date: 2021
    ISSN: 1139-6709
    DOI: http://dx.doi.org/10.1007/s10123-021-00208-7
  • Title: Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants
    Authors: , Makarova, Kira S; , Wolf, Yuri I; , Iranzo, Jaime; , Shmakov, Sergey A; , Alkhnbashi, Omer S; , Brouns, Stan J J; , Charpentier, Emmanuelle; , Cheng, David; , Haft, Daniel H; , Horvath, Philippe; , Moineau, Sylvain; Mojica, FJM; Scott, David; Shiraz, Shah; Siksnys, Virginijus; Terns, Michael; Venclovas, ¿eslovas; White, Malcolm F; , Yakunin A.F.; Yan, Winston; Feng, Zhang; , Garrett R.A.; , Backofen R; , van der Oost J.; , Barrangou R.; , Koonin E.V.
    Journals Nature Reviews Microbiology
    Volume: 18
    Pages: 67 - 83
    Date: 2020
    ISSN: 1740-1526
    DOI: http://dx.doi.org/10.1038/s41579-019-0299-x
  • Title: Efecto del pH del medio y de la concentración de iones magnesio sobre la actividad in vitro de temafloxacina (A-62254)
    Authors: , Muñoz, C.; CATALAN, V.; , Gimeno, C.; , García De Lomas, J.
    Journals Revista sin ISSN
    Volume:
    Pages: -
    Date:
    ISSN: 0000-0000
  • Title: Sequence diversity of the internal transcribed spacer (ITS) among different serogroups of Legionella pneumophila isolates
    Authors: , Pascual, L; , Pérez, S.; , Moreno, A.; , Amo, A.; , Apraiz, D.; CATALAN, V.
    Journals Revista sin ISSN
    Volume:
    Pages: -
    Date:
    ISSN: 0000-0000
  • Title: Deepening the knowledge of universal stress proteins in Haloferax mediterranei. Appl Microbiol Biotechnol. 2024;108(1):124. doi:10.1007/s00253-023-12899-1
    Authors: Matarredona L; Zafrilla, B.; Rubio-Portillo, E.; Bonete, M.J.; Esclapez, J.
    Journals Applied Microbiology and Biotechnology
    Volume: 108
    Pages: 124 -
    Date: 2024
    ISSN: 0175-7598
    DOI: http://dx.doi.org/10.1007/s00253-023-12899-1
  • Title: Global Lrp regulator protein from Haloferax mediterranei: Transcriptional analysis and structural characterization.
    Authors: Matarredona L; García-Bonete, M. J. ; Guío, Jorge; Camacho, M.; Fillat, María F.; Esclapez, J.; Bonete, M.J.
    Journals International Journal of Biological Macromolecules
    Volume: 260
    Pages: 129541 -
    Date: 2024
    ISSN: 0141-8130
    DOI: https://doi.org/10.1016/j.ijbiomac.2024.129541
  • Title: Iron-molybdenum focator synthesis by a thermophilic nitrogenase devoid of the scaffold NifEN
    Authors: Paya-Tormo, L. ; Echavarri Erasun, Carlos; Makarovsky Saavedra, Natalia; Pérez González, Ana; Yong Yang, Zhi; Guo, Yisong; Seefeldt, Lance C.; Rubio Herrero, Luis M.
    Journals Proceedings of the National Academy of Sciences of the United States of America (Online)
    Volume: 121
    Pages: -
    Date: 2024
    ISSN: 1091-6490
    DOI: doi.org/10.1073/pnas.2406198121
RELEVANT PUBLISHED BOOKS
No data.
RELEVANT PUBLISHED BOOK CHAPTERS
  • Book chapter title: Discovery and Seminal Developments in the CRISPR field
    Authors: Mojica, FJM; , Garrett, R.
    Editorial: Springer Berlin / Heidelberg
    Pages: 1 - 32
    Date: 2013
    ISBN:
    Book title: CRISPR-Cas Systems: RNA-mediated adaptive immunity in Bacteria and Archaea

    DOI: 10.1007/978-3-642-34657-6_1
  • Book chapter title: Response to Osmotic Stress in a Haloarchaeal Genome: a Role for General Stress Proteins and Global Regulatory Mechanisms
    Authors: , Juez, G; , Fenosa, D.; , Gonzaga A; Soria, E.; Mojica, FJM
    Editorial: ASM Press (American Society for Microbiology)
    Pages: 232 - 240
    Date: 2007
    ISBN:
    Book title: Physiology and Biochemistry of Extremophiles
  • Book chapter title: Antiarchaeal Antibiotics.
    Authors: Mojica, FJM
    Editorial: Research Singpost
    Pages: 83 - 108
    Date: 2003
    ISBN:
    Book title: New approach in the use of antibiotics.
  • Book chapter title: Genetic diversity in uropathogenic Escherichia coli as shown by RAPD (Random Amplified Polymorphic DNA), 16S-23S RDNA spacers and adhesin gene restriction patterns.
    Authors: Rodríguez-Valera, F.; García-Martínez, J.; Zorraquino, A.; Martínez-Murcia, A.J.
    Editorial:
    Pages: 65 - 68
    Date: 1997
    ISBN:
    Book title: Ecology of Pathogenic Bacteria, Molecular and Evolutionary Aspects.
  • Book chapter title: Fundamentos de la PCR en Microbiología
    Authors: CATALAN, V.
    Editorial: Unipath
    Pages: 80 - 81
    Date: 1993
    ISBN:
    Book title: Aplicaciones de la PCR al control microbiológico del agua
  • Book chapter title: INVES 10: Evaluación colaborativa de aprendizajes mediante e-rúbricas en Iniciación a la Investigación en Biología
    Authors: Girela, J. L.; Bonet, A.; Sánchez Sánchez, A.; Casas, J.L.; De Juan, E.; García-Martínez, J.; Garmendia, I.; Giannetti, A.; Maldonado-Caro, R.
    Editorial:
    Pages: 1571 - 1595
    Date:
    ISBN:
    Book title:  Memorias del Programa de Redes-I3CE de calidad, innovación e investigación en docencia universitaria. Convocatoria 2020-21

    RUA: http://hdl.handle.net/10045/120837
  • Book chapter title: INVES9: El trabajo colaborativo en el aprendizaje basado en proyectos en Iniciación a la Investigación en Biología
    Authors: Bonet, A.; Sánchez Sánchez, A.; , Sánchez; Casas, J.L.; , J.L. Casas, J.L.; De Juan, E.; Garmendia, I.; Girela, J. L.; García-Martínez, J.; Maldonado-Caro, R.; , Maldonado, R.D.; Martínez-Espinosa, R.M.
    Editorial: Instituto de Ciencias de la Educación (ICE) de la Universidad de Alicante
    Pages: 549 - 556
    Date: 2020
    ISBN:
    Book title: Memorias del Programa de Redes-I3CE de calidad, innovación e investigación en docencia universitaria.Convocatoria 2019-20.

    RUA: http://hdl.handle.net/10045/110633
  • Book chapter title: INVES 8: Diagnóstico del trabajo grupal y mejora de las estrategias y metodologías docentes en Iniciación a la investigación en Biología
    Authors: Girela, J. L.; Bonet, A.; Sánchez Sánchez, A.; Casas, J.L.; De Juan, E.; Garmendia, I.; García-Martínez, J.; Maldonado-Caro, R.; Pire, C.
    Editorial:
    Pages: 803 - 827
    Date: 2019
    ISBN:
    Book title: Memòries del Programa de Xarxes-I3CE de qualitat, innovació i investigació en docència universitària. Convocatòria 2018-19

    RUA: http://hdl.handle.net/10045/99929
  • Book chapter title: Prólogo
    Authors: Mojica, FJM
    Editorial: Next Door Publishers
    Pages: 21 - 27
    Date: 2019
    ISBN:
    Book title: Editando genes: recorta, pega y colorea. Las maravillosas herramientas CRISPR.
  • Book chapter title: INVES 7: Diagnóstico y mejora de las estrategias y metodologías docentes en Iniciación a la investigación en Biología
    Authors: Girela, J. L.; Bonet, A.; Sánchez Sánchez, A.; Casas, J.L.; De Juan, E.; Garmendia, I.; García-Martínez, J.; Guerrero, JR; Maldonado-Caro, R.; Pire, C.; Valdecantos, A.
    Editorial:
    Pages: 899 - 919
    Date: 2018
    ISBN:
    Book title: Memorias del Programa de Redes-I3CE de calidad, innovación e investigación en docencia universitaria. Convocatoria 2017-18

    RUA: http://hdl.handle.net/10045/89030
RELEVANT CONFERENCE PAPERS
  • Title: Over three decades devoted to CRISPR
    Authors: Mojica, FJM
    Type of participation: Ponencia invitada
    Conference name: 35 Annual Conference of Academia Europaea and Conference of the Young Academy of Europe
    Event type: Europeo
    City of performance: Wroclaw (POLONIA)
    Date of performance: 26/11/2024
  • Title: Screening the tolerance of halophilic microorganisms to nitrogen
    Authors: Zafrilla, B.; Cuerda Coral, Alejandro; Rodes Cuartero, Laura; Matarredona L; Zafrilla-Requena, G. ; Camacho, M.; Esclapez, J.
    Type of participation: Póster
    Conference name: 27th EUROPEAN NITROGEN CYCLE MEETING & XVI REUNIÓN NACIONAL DEL METABOLISMO DEL NITRÓGENO
    Event type: Internacional
    City of performance: Granada (GRANADA) (ESPAÑA)
    Date of performance: 01/10/2024
  • Title: Transcriptional regulator Lrp from Haloferax mediterranei: transcriptional analysis and structural characterization
    Authors: Matarredona L; García-Bonete, M. J. ; Guío, Jorge; Camacho, M.; Fillat, María F.; Esclapez, J.; Bonete, M.J.
    Type of participation: Comunicación
    Conference name: 27th EUROPEAN NITROGEN CYCLE MEETING & XVI REUNIÓN NACIONAL DEL METABOLISMO DEL NITRÓGENO
    Event type: Internacional
    City of performance: Granada (GRANADA) (ESPAÑA)
    Date of performance: 01/10/2024
  • Title: Edición genética CRISPR
    Authors: Mojica, FJM
    Type of participation: Comité científico
    Conference name: XII World Congress on Bioethics
    Event type: Internacional
    City of performance: Gijon (ASTURIAS) (ESPAÑA)
    Date of performance: 13/05/2024
  • Title: Characterization of novel Cas9 nucleases from the deep ocean
    Authors: Cerón, Julián; Olaso, Alba; Sánchez, Pablo; Vicencio, Jeremy; Mingarro, Gerard; Rajkovski, Dejan; Colizzi, Francesco; Hernandes Coutinho, Felipe; Sanchez-Bolaños, Carlos; Moreno-Mateos, MIguel A.; Vazquez-Vilar, Marta; Orzáez, Diego; Sanchéz-Amat, Antonio; Mojica, FJM; , Silvia G. Acinas
    Type of participation: Ponencia
    Conference name: EMBO Workshop CRISPR-Cas. From Biology to therapeutic applications
    Event type: Internacional
    City of performance: Sevilla (SEVILLA) (ESPAÑA)
    Date of performance: 07/11/2023
  • Title: CRISPR vs. CRISPR
    Authors: Rosselli, R. ; Espinosa J.; Guzmán, NM.; Mojica, FJM
    Type of participation: Ponencia invitada
    Conference name: EMBO Workshop CRISPR-Cas. From Biology to therapeutic applications
    Event type: Internacional
    City of performance: Sevilla (SEVILLA) (ESPAÑA)
    Date of performance: 07/11/2023
  • Title: Exploring the potential of CRISPR-Cas module transfers between bacteria lineages to overcome Anti-CRISPR inhibition
    Authors: Rosselli, R. ; Guzmán, NM.; Espinosa J.; Mojica, FJM
    Type of participation: Ponencia
    Conference name:
    Event type: Internacional
    City of performance: (ESPAÑA)
    Date of performance: 25/10/2023
  • Title: Avances en la regulación del metabolismo del Nitrógeno en Haloarchaea: función del regulador transcripcional lrp
    Authors: Matarredona L; Pastor-Soler,S.; Zafrilla, B.; BONETE PEREZ, MARIA JOSE; Esclapez Espliego, Julia Maria
    Type of participation: Póster
    Conference name:
    Event type: Nacional
    City of performance: (ESPAÑA)
    Date of performance: 05/09/2023
  • Title: Avances en la regulación del metabolismo del Nitrógeno en Haloarchaea: función del regulador transcripcional lrp
    Authors: Matarredona L; Pastor-Soler,S.; Zafrilla, B.; Bonete, M.J.; Esclapez, J.
    Type of participation: Póster
    Conference name: 45º Congreso de la Sociedad Española de Bioquímica y Biología Molecular
    Event type: Nacional
    City of performance: Zaragoza (ZARAGOZA) (ESPAÑA)
    Date of performance: 05/09/2023
  • Title: Optimización de la producción de ficoeritrobilina y ficocianobilina
    Authors: Esclapez, J.; Matarredona L; Zafrilla Requena, Guillermo; Bonete, M.J.; Zafrilla, B.
    Type of participation: Póster
    Conference name: 45º Congreso de la SEBBM
    Event type: Nacional
    City of performance: Zaragoza (ZARAGOZA) (ESPAÑA)
    Date of performance: 05/09/2023