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Research groups
  Molecular Microbiology

General data

Field of study:
Experimental Sciences
Website:
E-mail:
Telephone:
+34 965903400 x 9761
Telephone:
+34 96 590 2162

Annual reports

Annual report
  • Study of repeated sequences in prokaryotes
    Caracterización de las secuencias repetidas CRISPR (Clustered regularly interspaced short palindromic repeats) de procariotas. Significado funcional y aplicaciones en tipificación molecular. Implicaciones evolutivas. Componentes de un sitema de inmunidad frente a elementos genéticos foráneos basado en las repeticiones CRISPR. Aplicaciones en biotecnología y clínica.

 

 

Services offered

Growth and manipulation of microorganisms. Detection and identification of microorganisms by molecular and culture methods. Genetic modification of prokaryotes. Analysis of gene expression in prokaryotes. Microbiological analysis of food.

 

 

Results

Identification in prokaryotes of a new genetic barrier against transmissible elements (plasmids and viruses) Development of a method for molecular typing of prokaryotes based on PCR amplification of CRISPR elements. Induction in prokaryotes of immunity against virus infection. Identification of virus components to be used as antibacterials.

 

 

Available relevant infrastructure

Basic equipment for experimentation in microbiology and molecular biology.

 

 

RELEVANT CONTRIBUTIONS TO RESEARCH PROJECTS
  • Project title: Agente de innovación para potenciar la transferencia de la tecnología generada en la Universidad de Alicante en el campo de la Microbiología al entono empresarial de la Comunidad Valenciana
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: AGENCIA VALENCIANA DE LA INNOVACION
    Starting date: 01/01/2020
    Termination date: 31/12/2021
  • Project title: Detección y caracterización de nuevos sistemas CRISPR-Cas
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: GENERALITAT VALENCIANA
    Starting date: 01/11/2017
    Termination date: 31/10/2021
  • Project title: Bacteriophage lysins as alternatives to antimicrobial treatment - BLAAT
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: MINISTERIO DE ECONOMIA Y EMPRESA
    Starting date: 01/04/2016
    Termination date: 31/03/2019
  • Project title: Inmunización en bacterias: adaptación del sistema CRISPR-Cas-I-E de Escherichia coli y Salmonella enterica
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: MINISTERIO DE ECONOMIA Y EMPRESA
    Starting date: 01/01/2015
    Termination date: 31/12/2019
  • Project title: Caracterización del sistema CRISPR/CAS-Y de Escherichia coli
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: MINISTERIO DE ECONOMIA Y EMPRESA
    Starting date: 01/01/2012
    Termination date: 31/12/2014
  • Project title: Biotecnología de Extremófilos (BIOTECEXTREM) - VIGROB-016
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: UNIVERSIDAD DE ALICANTE
    Starting date: 01/01/2024
    Termination date: 31/12/2024
  • Project title: Biotecnología de Extremófilos (BIOTECEXTREM) - VIGROB-016
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: UNIVERSIDAD DE ALICANTE
    Starting date: 01/01/2024
    Termination date: 31/12/2024
  • Project title: Microbiología molecular - VIGROB-086
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: UNIVERSIDAD DE ALICANTE
    Starting date: 01/01/2024
    Termination date: 31/12/2024
  • Project title: Microbiología molecular - VIGROB-086
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: UNIVERSIDAD DE ALICANTE
    Starting date: 01/01/2024
    Termination date: 31/12/2024
  • Project title: Biotecnología de Extremófilos (BIOTECEXTREM) - VIGROB-016
    Competitive: Yes
    European: No
    Public: Yes
    Project sponsors: UNIVERSIDAD DE ALICANTE
    Starting date: 01/01/2023
    Termination date: 31/12/2023

Publications See search box

RELEVANT CONTRIBUTIONS IN JOURNALS
  • Title: Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants
    Authors: , Makarova, Kira S; , Wolf, Yuri I; , Iranzo, Jaime; , Shmakov, Sergey A; , Alkhnbashi, Omer S; , Brouns, Stan J J; , Charpentier, Emmanuelle; , Cheng, David; , Haft, Daniel H; , Horvath, Philippe; , Moineau, Sylvain; Mojica, FJM; Scott, David; Shiraz, Shah; Siksnys, Virginijus; Terns, Michael; Venclovas, ¿eslovas; White, Malcolm F; , Yakunin A.F.; Yan, Winston; Feng, Zhang; , Garrett R.A.; , Backofen R; , van der Oost J.; , Barrangou R.; , Koonin E.V.
    Journals Nature Reviews Microbiology
    Volume: 18
    Pages: 67 - 83
    Date: 2020
    ISSN: 1740-1526
    DOI: http://dx.doi.org/10.1038/s41579-019-0299-x
  • Title: The CRISPR conundrum: evolve and maybe die, or survive and risk stagnation
    Authors: García-Martínez, J.; Maldonado-Caro, R.; Marco Guzmán, N.; Mojica, FJM
    Journals Microbial Cell
    Volume: 5
    Pages: 262 - 268
    Date: 2018
    ISSN: 2311-2638
    DOI: http://dx.doi.org/10.15698/mic2018.06.634
  • Title: Next-generation precision antimicrobials: towards personalized treatment of infectious diseases
    Authors: , de la Fuente-Núñez, C.; , Torres, M.D.T.; Mojica, FJM; , Lu, T.K.
    Journals Current Opinion in Microbiology
    Volume: 37
    Pages: 95 - 102
    Date: 2017
    ISSN: 1369-5274
    DOI: https://doi.org/10.1016/j.mib.2017.05.014
  • Title: Leuconostoc mesenteroidesandLeuconostoc pseudomesenteroides bacteriophages: Genomics and cross-species host ranges.
    Authors: , Pujato, S.A.; , Guglielmotti, D.M.; Martínez-García, M.; , Quiberoni,A.; Mojica, FJM
    Journals International Journal of Food Microbiology
    Volume: 257
    Pages: 128 - 137
    Date: 2017
    ISSN: 0168-1605
    DOI: http://dx.doi.org/10.1016/j.ijfoodmicro.2017.06.009
  • Title: Anti-cas spacers in orphan CRISPR4 arrays prevent uptake of active CRISPR¿Cas I-F systems
    Authors: Almendros, C.; Marco Guzmán, N.; García-Martínez, J.; Mojica, FJM
    Journals Nature Microbiology (Online)
    Volume: 1
    Pages: 16081 -
    Date: 2016
    ISSN: 2058-5276
    DOI: http://dx.doi.org/10.1038/NMICROBIOL.2016.81
  • Title: Efecto del pH del medio y de la concentración de iones magnesio sobre la actividad in vitro de temafloxacina (A-62254)
    Authors: , Muñoz, C.; CATALAN, V.; , Gimeno, C.; , García De Lomas, J.
    Journals Revista sin ISSN
    Volume:
    Pages: -
    Date:
    ISSN: 0000-0000
  • Title: Sequence diversity of the internal transcribed spacer (ITS) among different serogroups of Legionella pneumophila isolates
    Authors: , Pascual, L; , Pérez, S.; , Moreno, A.; , Amo, A.; , Apraiz, D.; CATALAN, V.
    Journals Revista sin ISSN
    Volume:
    Pages: -
    Date:
    ISSN: 0000-0000
  • Title: Deepening the knowledge of universal stress proteins in Haloferax mediterranei. Appl Microbiol Biotechnol. 2024;108(1):124. doi:10.1007/s00253-023-12899-1
    Authors: Sanchez-Matarredona, L. ; Zafrilla, B.; Rubio-Portillo, E.; Bonete, M.J.; Esclapez, J.
    Journals Applied Microbiology and Biotechnology
    Volume: 108
    Pages: 124 -
    Date: 2024
    ISSN: 0175-7598
    DOI: http://dx.doi.org/10.1007/s00253-023-12899-1
  • Title: Global Lrp regulator protein from Haloferax mediterranei: Transcriptional analysis and structural characterization.
    Authors: Sanchez-Matarredona, L. ; García-Bonete, M. J. ; Guío, Jorge; Camacho, M.; Fillat, María F.; Esclapez, J.; Bonete, M.J.
    Journals International Journal of Biological Macromolecules
    Volume: 260
    Pages: 129541 -
    Date: 2024
    ISSN: 0141-8130
    DOI: https://doi.org/10.1016/j.ijbiomac.2024.129541
  • Title: Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins
    Authors: Alonso-Lerma, B; Jabalera, Y; Samperio, S; Morin, M; Fernandez, A; Hille, LT; Silverstein, RA; Quesada-Ganuza, A; Reifs, A; Fernández-Peñalver, S; , Benitez, Y.; Soletto, L; Gavira, JA; Diaz, A; Vranken, W; Sanchez-Mejias, A; Güell, M; Mojica, FJM; Kleinstiver, BP; Moreno-Pelayo, MA; , Montoliu, L.; Perez-Jimenez, R
    Journals Nature Microbiology (Online)
    Volume: 8
    Pages: 77 - 90
    Date: 2023
    ISSN: 2058-5276
    DOI: http://dx.doi.org/10.1038/s41564-022-01265-y
RELEVANT PUBLISHED BOOKS
No data.
RELEVANT PUBLISHED BOOK CHAPTERS
  • Book chapter title: INVES9: El trabajo colaborativo en el aprendizaje basado en proyectos en Iniciación a la Investigación en Biología
    Authors: Bonet, A.; Sánchez Sánchez, A.; , Sánchez; Casas, J.L.; , J.L. Casas, J.L.; De Juan, E.; Garmendia, I.; Girela, J. L.; García-Martínez, J.; Maldonado-Caro, R.; , Maldonado, R.D.; Martínez-Espinosa, R.M.
    Editorial: Instituto de Ciencias de la Educación (ICE) de la Universidad de Alicante
    Pages: 549 - 556
    Date: 2020
    ISBN:
    Book title: Memorias del Programa de Redes-I3CE de calidad, innovación e investigación en docencia universitaria.Convocatoria 2019-20.

    RUA: http://hdl.handle.net/10045/110633
  • Book chapter title: Prólogo
    Authors: Mojica, FJM
    Editorial: Next Door Publishers
    Pages: 21 - 27
    Date: 2019
    ISBN:
    Book title: Editando genes: recorta, pega y colorea. Las maravillosas herramientas CRISPR.
  • Book chapter title: La taréa del Científico
    Authors: Mojica, FJM
    Editorial: Colección Picayo
    Pages: 19 - 19
    Date: 2017
    ISBN:
    Book title: Alberto Sols y la Bioquímica
  • Book chapter title: Salinibacter ruber: The Never Ending Microdiversity?
    Authors: Peña, A.; , Gomariz, M.; , Lucio, M.; , González-Torres, P.; , Huertas-Cepa, J.; , Martínez-García, M.; , Santos, F.; , Schmitt-Kopplin, P.; , Gabaldón, T.; , Rossello-Mora, R.; Antón, J.
    Editorial: Caister Academic Press
    Pages: -
    Date: 2014
    ISBN:
    Book title: Halophiles. Genetics and Genomes
  • Book chapter title: Coordinación de actividades docentes presenciales y no presenciales en el Máster en Ciencias de los Alimentos y Nutrición
    Authors: Mora, J.; , Mora Pastor, J.; Gras, L.; , Bonete Pérez, M.J.; Grindlay, G.; , Camacho Carrasco, M.; , Carballo-Marrero, S.; Lax, P.; , Cerdán-Sala, M.M.; Mojica, FJM; , Gras García, L.; , Grindlay Lledó, G.; HURTADO SANCHEZ, J.A.; , Juárez Sanz, M.; , Lax Zapata, P.; , Maestre
    Editorial: ICE/Vicerrectorado de Estudios e Innovación Educativa, Universidad de Alicante
    Pages: 1183 - 1192
    Date: 2013
    ISBN:
    Book title: Diseño de acciones de investigación en docencia universitaria

    RUA: http://hdl.handle.net/10045/25861
  • Book chapter title: Discovery and Seminal Developments in the CRISPR field
    Authors: Mojica, FJM; , Garrett, R.
    Editorial: Springer Berlin / Heidelberg
    Pages: 1 - 32
    Date: 2013
    ISBN:
    Book title: CRISPR-Cas Systems: RNA-mediated adaptive immunity in Bacteria and Archaea

    DOI: 10.1007/978-3-642-34657-6_1
  • Book chapter title: Grado en biología - coordinación de tercer curso.   
    Authors: Martínez-Espinosa, R.M.; Mojica, FJM; , Bonet Jornet, A.; , Bautista Aguilar, S.; , Casas-Martínez, J.L.; , Contreras De Vera, A.; , Cortina i Segarra,J.; , Ivorra Pastor, I; , Jordá-Guijarro, J.D.; , López-Iborra G
    Editorial: ICE/Vicerrectorado de Estudios e Innovación Educativa, Universidad de Alicante
    Pages: 720 - 732
    Date: 2013
    ISBN:
    Book title: Diseño de acciones de investigación en docencia universitaria

    RUA: http://hdl.handle.net/10045/25861
  • Book chapter title: Grado en geología - coordinación de tercer curso
    Authors: Cañaveras, J.C.; , Alfaro, P.; Benavente, D.; Mojica, FJM; , Estévez, A.; , Giannetti, A.; , Giner, J.J.; , Martín-Martín, M.; , Martín Rojas, I; Martínez-Martínez,J.; , Tent-Manclús, J.E
    Editorial: ICE/Vicerrectorado de Estudios e Innovación Educativa, Universidad de Alicante
    Pages: 398 - 417
    Date: 2013
    ISBN:
    Book title: Diseño de acciones de investigación en docencia universitaria

    RUA: http://hdl.handle.net/10045/25861
  • Book chapter title: From genomics to microevolution and ecology: the case of Salinibacter ruber
    Authors: Antón, J.; , Peña; Santos, F.; Peña, A.; , Teeling; , Huerta-Cepas; , Santos; , Meseguer; , Lucio; , Schmitt-Kopplin; , Dopazo; , Rosselló-Móra; , Schüler; , Glöckner; , Amann; , Gabaldón; , Antón
    Editorial: Springer-Verlag
    Pages: 109 - 122
    Date: 2011
    ISBN:
    Book title: Halophiles and Hypersaline Environments.

    DOI: 10.1007/978-3-642-20198-1
  • Book chapter title: Response to Osmotic Stress in a Haloarchaeal Genome: a Role for General Stress Proteins and Global Regulatory Mechanisms
    Authors: , Juez, G; , Fenosa, D.; , Gonzaga A; Soria, E.; Mojica, FJM
    Editorial: ASM Press (American Society for Microbiology)
    Pages: 232 - 240
    Date: 2007
    ISBN:
    Book title: Physiology and Biochemistry of Extremophiles
RELEVANT CONFERENCE PAPERS
  • Title: Characterization of novel Cas9 nucleases from the deep ocean
    Authors: Cerón, Julián; Olaso, Alba; Sánchez, Pablo; Vicencio, Jeremy; Mingarro, Gerard; Rajkovski, Dejan; Colizzi, Francesco; Hernandes Coutinho, Felipe; Sanchez-Bolaños, Carlos; Moreno-Mateos, MIguel A.; Vazquez-Vilar, Marta; Orzáez, Diego; Sanchéz-Amat, Antonio; Mojica, FJM; , Silvia G. Acinas
    Type of participation: Ponencia
    Conference name: EMBO Workshop CRISPR-Cas. From Biology to therapeutic applications
    Event type: Internacional
    City of performance: Sevilla (SEVILLA) (ESPAÑA)
    Date of performance: 07/11/2023
  • Title: CRISPR vs. CRISPR
    Authors: Rosselli, R. ; Espinosa J.; Marco Guzmán, N.; Mojica, FJM
    Type of participation: Ponencia invitada
    Conference name: EMBO Workshop CRISPR-Cas. From Biology to therapeutic applications
    Event type: Internacional
    City of performance: Sevilla (SEVILLA) (ESPAÑA)
    Date of performance: 07/11/2023
  • Title: Exploring the potential of CRISPR-Cas module transfers between bacteria lineages to overcome Anti-CRISPR inhibition
    Authors: Rosselli, R. ; Marco Guzmán, N.; Espinosa J.; Mojica, FJM
    Type of participation: Ponencia
    Conference name:
    Event type: Internacional
    City of performance: (ESPAÑA)
    Date of performance: 25/10/2023
  • Title: Optimización de la producción de ficoeritrobilina y ficocianobilina
    Authors: Esclapez, J.; Sanchez-Matarredona, L. ; Zafrilla Requena, Guillermo; Bonete, M.J.; Zafrilla, B.
    Type of participation: Póster
    Conference name: 45º Congreso de la SEBBM
    Event type: Nacional
    City of performance: Zaragoza (ZARAGOZA) (ESPAÑA)
    Date of performance: 05/09/2023
  • Title: Structural studies of the Lrp transcription factor regulator of the haloarchaeon Haloferax mediterranei.
    Authors: García-Bonete, M. J. ; Sanchez-Matarredona, L. ; Camacho, M.; Esclapez, J.; Bonete, M.J.
    Type of participation: Póster
    Conference name: 45º Congreso de la SEBBM
    Event type: Nacional
    City of performance: Zaragoza (ZARAGOZA) (ESPAÑA)
    Date of performance: 05/09/2023
  • Title: Biotechnological applications of CRISPR tools
    Authors: Montoliu, Lluís; Fernández, Almudena; Perez-Jimenez, R; Mojica, FJM
    Type of participation: Ponencia invitada
    Conference name: XVIII Congreso de la Sociedad Española de Biotecnología, SEBiot 2023
    Event type: Nacional
    City of performance: Madrid (MADRID) (ESPAÑA)
    Date of performance: 17/07/2023
  • Title: Horizontal transfer of adaptation and effector modules as a potential mechanism for overcoming CRISPR-Cas system inhibitions
    Authors: Rosselli, R. ; Marco Guzmán, N.; Espinosa J.; Mojica, FJM
    Type of participation: Póster
    Conference name: CRISPR CONFERENCE 2023
    Event type: Internacional
    City of performance: Wu¿rzburg (ALEMANIA)
    Date of performance: 27/06/2023
  • Title: Characterisation of Type IV CRISPR/Cas-carrying plasmids in Klebsiella spp.
    Authors: Fernández-Favieres, Francisco Javier; Serna, Carlos; Dolcet-Negre, Marta M; Pulido-Vadillo, Mario; Montero, Natalia; , Riccardo Rosselli; Mojica, FJM; Gonzalez-Zorn, Bruno
    Type of participation: Póster
    Conference name: XIII Reunión del Grupo de Microbiología Molecular de la Sociedad Española de Microbiología
    Event type: Nacional
    City of performance: Granada (GRANADA) (ESPAÑA)
    Date of performance: 07/09/2022
  • Title: Desarrollo de estrategias basadas en endolisinas para el control de patógenos vegetales
    Authors: García-Martínez, J.
    Type of participation: Ponencia invitada
    Conference name: València BC: Simposi Internacional sobre Biocontrol en Agricultura Comunitat Valenciana
    Event type: Internacional
    City of performance: Valencia (VALENCIA/ VALÈNCIA) (ESPAÑA)
    Date of performance: 04/07/2022
  • Title: The joy of CRISPR discovery
    Authors: Mojica, FJM
    Type of participation: Ponencia invitada
    Conference name: IX International Symposium SRUK/CERU
    Event type: Internacional
    City of performance: Oxford (REINO UNIDO (Gran Bretaña e Irlanda del Norte))
    Date of performance: 01/07/2022